Sofosbuvir + velpatasvir

Y. Vivian Tsai, Pharm.D., Janessa M. Smith, PharmD, BCPS

INDICATIONS

FDA

  • Treatment of adults and pediatric patients ≥3 years with chronic HCV genotype 1–6 infection without cirrhosis or with compensated cirrhosis; or with decompensated cirrhosis in combination with ribavirin.

NON-FDA APPROVED USES

  • Acute HCV infection
    • Current AASLD/IDSA guidance recommends treating acute viremic HCV without waiting for spontaneous clearance, using the same regimens as chronic HCV; abbreviated SOF/VEL courses are not recommended.[9]

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Last updated: October 7, 2026