Johns Hopkins ABX Guide
Streptomycin
INDICATIONS
FDA
FDA
- Mycobacterium tuberculosis
- An infrequently used alternative component of combination therapy when susceptibility is demonstrated and preferred oral agents are unavailable or not feasible.
- Yersinia pestis (plague)
- Francisella tularensis (tularemia)
- 2025 CDC tularemia recommendations relegate streptomycin to third-tier treatment because of toxicity, limited availability, and unfamiliarity with its preparation and administration.
- Brucella infection
- Used in combination with doxycycline
- Historical FDA indications: Streptomycin is not generally used for these infections because safer and more effective alternatives are available.
- Klebsiella granulomatis (Donovanosis, granuloma inguinale)
- Haemophilus ducreyi (chancroid); Haemophilus influenzae
- Urinary tract infections
- Gram-negative bacillary bacteremia (concomitantly with another antibacterial agent)
- Enterococcal endocarditis
- The 2026 AHA statement favors ampicillin plus ceftriaxone for susceptible E. faecalis endocarditis; streptomycin is not included among its recommended regimens[10].
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Last updated: October 11, 2026
Citation
Auwaerter, Paul G, and Caitlin Soto. "Streptomycin." Johns Hopkins ABX Guide Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Johns Hopkins Guides, hopkinsguides.org/hopkins/view/Johns_Hopkins_ABX_Guide/540526/all/Streptomycin.
Auwaerter PG, Soto C. Streptomycin. Johns Hopkins ABX Guide Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://hopkinsguides.org/hopkins/view/Johns_Hopkins_ABX_Guide/540526/all/Streptomycin. Accessed October 13, 2026.
Auwaerter, P. G., & Soto, C. (2026). Streptomycin. In Johns Hopkins ABX Guide Johns Hopkins ABX Guide. The Johns Hopkins University. https://hopkinsguides.org/hopkins/view/Johns_Hopkins_ABX_Guide/540526/all/Streptomycin
Auwaerter PG, Soto C. Streptomycin [Internet]. In: Johns Hopkins ABX Guide Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 October 13]. Available from: https://hopkinsguides.org/hopkins/view/Johns_Hopkins_ABX_Guide/540526/all/Streptomycin.
* Article titles in AMA citation format should be in sentence-case
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T1 - Streptomycin
ID - 540526
A1 - Auwaerter,Paul,M.D.
AU - Soto,Caitlin,PharmD, BCIDP
Y1 - 2026/10/11/
BT - Johns Hopkins ABX Guide
UR - https://hopkinsguides.org/hopkins/view/Johns_Hopkins_ABX_Guide/540526/all/Streptomycin
PB - The Johns Hopkins University
DB - Johns Hopkins Guides
DP - Unbound Medicine
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