Cidofovir

Y. Vivian Tsai, Pharm.D., Paul G. Auwaerter, M.D.

INDICATIONS

FDA

  • Treatment of CMV retinitis in patients with AIDS.
    • IV cidofovir is an alternative when ganciclovir/valganciclovir and foscarnet cannot be used; toxicity limits its use[1][3][25].

NON-FDA APPROVED USES

Intravenous Injections

  • Refractory/resistant CMV DNAemia in transplant recipients
  • Treatment of non-retinitis CMV infections (e.g., viremia, colitis, and pneumonitis)
  • Treatment of adenovirus infections
  • Treatment of acyclovir-resistant HSV
  • Severe/refractory BK virus hemorrhagic cystitis after HCT, benefit uncertain

Topical Application

  • Treatment of acyclovir-resistant HSV

Intralesional Injections

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